Department of Integrative Biology
3060 Valley Life Sciences Building - #3140
Berkeley, CA 94720-3140
Office TEL (510) 643-4605
Lab TEL (510) 643-4201 (LSA)
Lab TEL (510) 643-6227 (VLSB)
FAX (510) 643-5022 email: nipam@uclink.berkeley.edu
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Education and Research Positions:
University of California, Berkeley
Professor, Dept. of Molec. & Cell Biology and Dept of Integrative Biol.,
(Co-chair Dept. of Integrative Biol., Sept. 2007 - Feb. 2008)
Investigator, Howard Hughes Medical Institute
July 1, 2003 to August 31, 2010
National Institute of Genetics, Shizuoka, Japan
Adjunct Professor
2007 - Present
University of Chicago
Professor, Dept. of Organismal Biology and Anatomy
Associate Investigator, Howard Hughes Medical Insitute
1995 - 2003
Carnegie Institution
Dept. of Embryology
Staff Associate: June 1991 March 1995
Australian National University
Research School of Biological Sciences
Visiting Fellow: Jan. 1991 May 1991
University of California, Berkeley
Dept. of Molecular and Cell Biology
Sponsor: Dr. Corey S. Goodman
Postdoctoral Fellow: Jan. 1990 Dec. 1990
Stanford University
Dept. of Biological Sciences
Advisor: Dr. Corey S. Goodman
Ph.D. received Dec. 1989
Princeton University
Dept. of Biology
Advisor: Dr. Malcolm S. Steinberg
A.B. received June 1984
Awards and Fellowships:
NSF Predoctoral Fellowship, 1984 - 1987
Damon Runyon Walter Winchell Fellow, 1991 - 1992
McKnight Scholars Neuroscience Fellowship Award, 1992 - 1995
Professional Activities:
NHGRI Comparative Genome Evolution Working Group, 2004 – 2007
NIH Developmental Biology Expert Panel – 2006 Community Sequencing Program Review Panel, DOE/JGI, 2005 and 2006.
National Academies Committee on the Impact of High-end Computing 2006 – present
NSF/Sloan Molecular Evolution Postdoctoral Fellowship Panel (1995 - 1997)
Journal Editorial Boards
PLOS Biology; 2005 - present
Developmental Biology; 2007 - present
Annual Reviews of Ecology and Evolution; Guest Editor; 2007 - 2008
Development Genes and Evolution; 1996 - present
J. Experimental Zoology; 1997 - 2005
Evolution and Development; 1999 - present
Arthropod Structure and Development; 1999 - 2007
American Naturalist; 2003 - present
Other Positions
Co-Director, Woods Hole Embryology Course; 2007 - 2011
Scientific Content Director, Society for Developmental Biology Website; 2005 - 2008
Advisory Board, The Regeneration Project, University of Florida, McKnight Brain Institute; 2007 - present
Co-Director, Cold Spring Harbor Drosophila Neurobiology Course, 1996 - 1998
Publications:
Price, A.L., M.S. Modrell, R.L. Hannibal, N.H. Patel. (2009) Mesoderm and ectoderm lineages in the crustacean Parhyale hawaiensis display intra-germ layer compensation. Developmental Biology (In Press).
Patel, N.H. (2009) Asymmetry with a twist. Nature. 462 (7274): 727-728. [PDF file in new window]
Liubicich, D.M., J. Serano, A. Pavlopoulos, Z. Kontarakis, M.E. Protas, E. Kwan, S. Chatterjee, K.D. Tran, M. Averof, N. Patel. (2009) Knockdown of Parhyale Ultrabithorax recapitulates evolutionary changes in crustacean appendage morphology. PNAS. 106 (33): 13892-13896. [PDF file in new window]
Pavlopoulos, A., Z. Kontarakis, D. Liubicich, J.M. Serano, M. Akam, N.H. Patel, M. Averof. (2009) Probing the evolution of appendage specialization by Hox gene misexpression in an emerging model crustacean. PNAS. 106 (33): 13897-13902. [PDF file in new window]
Rehm, E.J., R.L. Hannibal, R.C. Chaw, M.A. Vargas-Vila and N.H. Patel. (2009) The crustacean Parhyale hawaiensis: a new model for arthropod development. In “Emerging Model Organisms, A Laboratory Manual” (Gann, A. & D. Crotty, eds.) Cold Spring Harbor Press, Cold Spring Harbor,NY. pp. 373-404.
Patel, N.H., P. Liu (2009) Segmentation. In “Encyclopedia of Insects, 2nd Edition” (Resh, V.H. & R.T. Carde, eds.) Academic Press/Elsevier Science, London, UK. pp. 909-912. [PDF file in new window}
Modrell, M.S., Price, A.L., Havemann, J., Extavour, C., Gerberding, M., Patel, N.H. Germcell replacement following ablation of primordial germ cells in Parhyale hawaiensis. Submitted.
Grande, C. and N.H. Patel (2009). Nodal signaling is involved in left-right asymmetry in snails. Nature. 457:1007-1011. [PDF] file in new window
Lyons, J.W., Arnett, D., Choudhary, A.N., Colella, P., Cracraft, J.L., Dutton, J.A., Edwards, S.V., Erickson III, D.J., Head-Gordon, T.L., Hernquist, L.E., Keller II, G.E., Patel, N.H., Rezac, M.E., Smith, R.B., Stone, J.M., Wooley, J.C. (2008). The Potential Impact of High-End Capability Computing On Four Illustrative Fields of Science and Engineering. The National Academies Press. Washington D.C. pp.1-126. [PDF] file in new window
VanHook A., N.H. Patel. (2008) Crustaceans. Curr Biol. 18(13):R547-50. [PDF] file in new window
Stillman, J.H., Colbourne, J.K., Lee, C.E., Patel, N.H., Phillips, M.R., Towle, D.W., Eads, B.D., Gelembuik, G.W., Henry, M.R., Johnson, E.A., Pfender, M.E., Terwilliger, N.B. (2008). Recent advances in crustacean genomics. Integrative and Comparative Biology. 48(6) 852-868. [PDF] file in new window
Protas, M. and N.H. Patel. (2008). Evolution of Coloration Patterns. In Annual Reviews of Cell and Developmental Biology, Vol. 24. (Schekman, R., Goldstein, L., Rossant, J. eds.) Annual Reviews, Palo Alto, CA. pp. 425-446. [PDF] file in new window
Price, A.L., and N.H. Patel (2008) Investigating divergent mechanisms of mesoderm development in arthropods: the expression of Ph-twist and Ph-mef2 in Parhyale hawaiensis. Journal of Experimental Zoology B Molecular and Developmental Evolution. 310: 24-40 [PDF] file in new window
Parchem, R.J., M.W. Perry, N.H. Patel. (2007) Patterns on the insect wing. Current Opinions in Genetics and Development. 17: 300-308. [PDF] file in new window
Barton, N.H., Briggs, D.E.G., Eisen, J.A., Goldstein, D.B., Patel, N.H. (2007). Evolution. Cold Spring Harbor Press, New York. 831 pages. [Link for further information]
Patel, N.H. (2006) Evolutionary biology: how to build a longer beak. Nature. 442 (7102): 515-516. [PDF] file in new window
Giorgianni, M, and N.H. Patel. (2005) Conquering Land, Air and Water: The Evolution and Development of Arthropod Appendages. In “Evolving Form and Function: Fossils and Development” (Briggs, Derek .E.G. ed.) Peabody Museum of Natural History, New Haven, CT. pp.159-180. [PDF] file in new window
Aboobaker, A.A., P. Tomancak, N.H. Patel, G.M. Rubin, E.C. Lai. (2005) Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. PNAS. 102: 18017-18022. [PDF] file in new window
Davis, G.K., J.A. D’Alessio, N.H. Patel. (2005) Pax 3/7 genes reveal conservation and divergence in the arthropod segmentation hierarchy. Dev. Biol. 285: 169-184.[PDF] file in new window
Babbitt, C.C., and N.H. Patel. (2005) Relationships within the Pancrustacea: Examining the influence of additional Malacostracan 18S and 28S rDNA. In “Crustacea and Arthropod Relationships” (Koenemann, S. & R. A. Jenner, eds.) Taylor & Francis, Davis, CA. pp. 275-294.
Lucchetta E.M., J.H. Lee, L.A. Fu, N.H. Patel, R.F. Ismagilov. (2005) Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature. 434:1134-1138. [PDF] file in new window
Browne W.E., A.L. Price, M. Gerberding, N.H. Patel. (2005) Stages of embryonic development in the amphipod crustacean, Parhyale hawaiensis. Genesis. 42:124-149.[PDF] file in new window
Oakley T.H., Z. Gu, E. Abouheif, N.H. Patel, W.H. Li. (2005) Comparative Methods for the Analysis of Gene Expression Evolution: An Example Using Yeast Functional Genomic Data. Mol. Biol. Evol. 22:40-50 [PDF] file in new window
Giorgianni, M.W. and N.H. Patel. (2004) Patterning of the branched head appendages in Schistocerca Americana and Tribolium castaneum. Evol Dev. 6: 402-410. [PDF] file in new windowBergman, C.M., and N.H. Patel. (2004) Identifying changes in cis-regulatory evolution: approaches and implications. In “Evolution: From Molecules to Ecosystems” (Moya, A. & E. Font, eds.) Oxford University Press, Oxford, UK. pp. 48-58.
Gerberding, M., N.H. Patel. (2004) Gastrulation in Crustaceans: Germ Layers and Cell Lineages. In “Gastrulation: From Cells to Embryo” (Claudio D. Stern, ed.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 79-89.
Price, A.L., N.H. Patel. (2004) The Evolution of Gastrulation: Cellular and Molecular Aspects. In “Gastrulation: From Cells to Embryo” (Claudio D. Stern, ed.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 695-701.
Patel N.H. (2004) Evolutionary Biology: Time, Space and Genomes. Nature 431: 28-29.[PDF] file in new window
Ting C.T., S.C.Tsaur, S.Sun,W.E. Browne, Y.C. Chen, N.H. Patel, C.I. Wu. (2004) Gene Duplication and speciation in Drosophila: evidence from the Odysseus Locus. Proc Natl Acad Sci U. S. A. 101: 12232-12235. [PDF] file in new window
Eichler, E. E. and N. H. Patel (2003) Genomes and evolution. From sequence to organism. Curr . Opin. Genet. Dev. 6:559-561.[PDF] file in new window
Fujioka, M., Lear, B.C., Landgraf, M., Yusibova, G.L., Zhou, J., Riley, K.M., Patel, N. H., and Jaynes, J. B. (2003) Even-skipped, acting as a repressor, regulates axonal projections in Drosophila, Development 22: 5385-5400.[PDF] file in new window
Patel, N.H. (2003) Segmentation. In “Encyclopedia of Insects” (Resh, V.H. & R.T. Carde, eds.) Academic Press/Elsevier Science, London, UK. pp. 1025-27.
Patel, N. H. (2003) The ancestry of segmentation. Dev. Cell 5:2-4.[PDF] file in new window
Davis, G.K., and N. H. Patel (2003) Playing by pair-rules? Bioessays, 25:425-429. [PDF] file in new window
Lall, S., Ludwig, M. Z., and N. H. Patel (2003). Nanos plays a conserved role in axial patterning outside of the diptera. Current Biology, 13:224-229. [PDF] file in new windowGerberding, M., Browne, W.E., and N. H. Patel (2002) Cell lineage analysis of the amphipod crustacean Parhyale hawaiensis reveals an early restriction of cell fates. Development 129:5789-5801. [PDF] file in new window
Fujioka, M., G.L. Yusibova, N. H. Patel, S. J. Brown, and J. B. Jaynes. (2002). The repressor activity of Even-skipped is highly conserved, and is sufficient to activate engrailed and to regulate both the spacing and stability of parasegment boundaries. Development 129: 4411-4421. [PDF] file in new window
Davis, G.K. and N.H. Patel (2002). Short, long and beyond: molecular and embryological aproaches to insect segmentation. Annual Reviews of Entomology 47:669-699. [PDF] file in new window
Patel, N.H. and S. Lall (2002). Precision patterning. Nature 415: 748-749. [PDF] file in new window
Gerberding, M. and N. H. Patel (2002) Developmental biologists cast a net over sequenced genomes. Genome Biol. 3:Reports4032. [PDF] file in new window
Duman-Scheel, M., N. Pirkl, and N. H. Patel (2002). Analysis of the expression pattern of Mysidium columbiae wingless provides evidence for conserved mesodermal and retinal patterning processes among insects and crustaceans. Dev. Genes Evol. 212:114-123. [PDF] file in new window
Lall, S. and N.H. Patel (2001). Conservation and divergence in molecular mechanisms of axis formation. Annual Reviews of Genetics 35:407-437. [PDF] file in new window
Takahashi, Y., N. Osumi, and N.H. Patel (2001). Body Patterning. Proc. Natl. Acad. Sci. USA 98: 12338-12339.[PDF] file in new window
Davis, G.K., Jaramillo, C.A. and Patel, N.H. (2001). Pax group III genes and the evolution of pair rule pattern. Development, 128: 3445-3458. [PDF] file in new window
Patel, N. H., D.C. Hayward, S. Lall, N. Pirkl, D. DiPietro and E.E. Ball. (2001). Grasshopper hunchback expression reveals conserved and novel aspects of axis formation and segmentation. Development, 128:3459-3472. [PDF] file in new window
Patel N.H. and V.E. Prince (2000) Beyond the Hox complex. Genome Biol. 1:1027.1-4. [PDF] file in new window
Ma L., N. Tamarina, Y. Wang, A. Kuznetsov, N. Patel, C. Kending, B.J. Hering, and L.H. Philipson (2000). Baculovirus-mediated gene transfer into pancreatic islet cells. Diabetes 49:1986-1991. [PDF] file in new window
Browne, W.E., and Patel, N.H. (2000) Molecular genetics of crustacean feeding appendage development and diversification. Semin. Cell. Dev. Biol. 11: 427-435. [PDF] file in new window
Patel, N. H. (2000). It's a bug's life. Proc. Natl. Acad. Sci. USA 97: 4442-4444. [PDF] file in new window
Ludwig, M.Z., C. Bergman, N. H. Patel, and M Kreitman (2000). Evidence for stabilizing selection in a eukaryotic cis-regulatory element. Nature, 403: 564-567. [PDF] file in new window
Davis, G.K., and N. H. Patel (1999). The origin and evolution of segmentation. Trends Genet., 15: M68-M72 (special joint millennium issue with TIBS & TCB). [PDF] file in new window
Oppenheimer, D.I., A.M. MacNicol, and N.H. Patel (1999). Functional conservation of wingless/engrailed interaction demonstrated by a widely applicable baculovirus misexpression system. Current Biology, 9: 1288-1296. [PDF] file in new window
Duman-Scheel, M., and N.H. Patel (1999). Analysis of molecular marker expression reveals neuronal homology in distantly related arthropods. Development 126: 2327-2334. [PDF] file in new window
Lear, B.C., J.B. Skeath, and N.H. Patel (1999). Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system. Mech. Dev. 88: 207-219. [PDF] file in new window
Marshall, C.R., H.A. Orr, and N.H. Patel (1999). Morphological innovation and developmental genetics. Proc. Natl. Acad. Sci. USA 96: 9995-9996. [PDF] file in new window
Palopoli, M.F., and N.H. Patel (1998). Evolution of the interaction between Hox genes and a downstream target. Current Biology 8: 587-590. [PDF] file in new window
Ludwig, M.Z., N. H. Patel, and M Kreitman (1998). Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. Development 125: 949-958. [PDF] file in new window
Averof, M. and N. H. Patel (1997). Crustacean appendage evolution associated with changes in Hox gene expression. Nature 388: 682-686. [PDF] file in new window
Duman-Scheel, M., X. Li, I. Orlov, M. Noll, and N. H. Patel (1997). Genetic separation of the neural and cuticular patterning functions of gooseberry. Development 124: 2855-2865. [PDF] file in new window
Abouheif E.,M. Akam, W.J. Dickinson, P.W. Holland, A. Meyer, N.H. Patel, R.A. Raff, V.L. Roth, and G.A. Wray (1997) Homology and developmental genes. Trends Genet. 13: 432-3. [PDF] file in new window
Romani, S., F. Jimenez, M. Hoch, N. H. Patel, H. Taubert, and H. Jackle (1996). Kruppel, a Drosophila segmentation gene, participates in the specification of neurons and glial cells. Mech. Dev. 60: 95-107. [PDF] file in new window
Palopoli, M.F., and N.H. Patel (1996). Neo-Darwinian developmental evolution: can we bridge the gap between pattern and process? Curr. Op. in Gen. and Dev. 6: 502-508. [PDF] file in new window
Patel, N.H. (1996). In situ hybridization to whole mount Drosophila embryos. In "A Laboratory Guide to RNA." (Paul A. Krieg, ed.) Wiley-Liss, New York, pp. 357-370.
Hayward, D.C., N.H. Patel, E.J. Rehm, C.S. Goodman, and E.E. Ball (1995). Sequence and expression of grasshopper antennapedia: comparison to Drosophila. Developmental Biology 172: 452-465. [PDF] file in new window
Chiang, C., N.H. Patel, K.E. Young, and P.A. Beachy (1994). The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells. Development 120: 3581-3593. [PDF] file in new window
Patel, N.H. (1994). Imaging neuronal subsets and other cell types in whole mount Drosophila embryos and larvae using antibody probes. In "Methods in Cell Biology, Vol 44. Drosophila melanogaster: Practical Uses in Cell Biology" (L.S.B. Goldstein and E. Fyrberg, eds.) Academic Press, New York pp. 445-487.
Patel, N.H. (1994). Developmental evolution: insights from studies of insect segmentation. Science 266: 581-590. [PDF] file in new window
Patel, N.H. (1994). Evolution of arthropod segmentation: insights from comparisons of gene expression patterns. Development Supplement. 201-207.
Condron, B.G., N.H. Patel, and K. Zinn (1994). engrailed controls glial/neuronal cell fate decisions at the midline of the central nervous system. Neuron 13: 541-554. [PDF] file in new window
Scholtz, G., N.H. Patel, and W. Dohle (1994). Serially homologous engrailed stripes are generated via different cell lineages in the germ band of amphipod crustaceans (Malacostraca, Peracarida). Int. J. Dev. Biol. 38: 471-478.
Patel, N.H. (1994). Evolution of insect patterning. Proc Natl Acad Sci. USA. 91: 7385-7386. [PDF] file in new window
Xiong, W-C., H. Okano, N.H. Patel, J.A. Blendy, and C. Montell (1994). repo encodes a glial-specific homeodomain protein required in the Drosophila nervous system. Genes Dev. 8: 981-994.
Patel, N.H., B.G. Condron, and K. Zinn (1994). Pair-rule expression patterns of even-skipped are found in both short and long germ beetles. Nature 367: 429-434. [PDF] file in new window
Brown, S.J., N.H. Patel, and R.E. Denell (1994). Embryonic expression of the single ribolium engrailed homolog. Developmental Genetics 15: 7-18.
Patel, N.H. (1993). Evolution of insect pattern formation: a molecular analysis of short germband segmentation. In Evolutionary Conservation of Developmental Mechanisms (ed. A. C. Spradling). Wiley-Liss, Inc., New York, pp. 85-110.
Gutjahr, T., N.H. Patel, X. Li, C.S. Goodman, and M. Noll (1993). Analysis of the gooseberry locus in Drosophila embryos: gooseberry determines the cuticular pattern and activates gooseberry neuro. Development 118: 21-31. [PDF] file in new window
Patel, N.H., E.E. Ball, and C.S. Goodman (1992). Changing role of even-skipped during the evolution of insect pattern formation. Nature 357: 339-342. [PDF] file in new window
Patel, N.H. and C.S. Goodman (1992). Preparation of digoxigenin-labeled single-stranded DNA probes. In Non-radioactive Labeling and Detection of Biomolecules (ed. C. Kessler). Springer-Verlag, Berlin, pp. 377-381.
Kolodkin, A.L., D.J. Matthes, T.P. O'Connor, N.H. Patel, A. Admon, D. Bentley, and C.S. Goodman (1992). Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron 9: 831-845. [PDF] file in new window
Grenningloh, G., A.J. Bieber, E.J. Rehm, P.M. Snow, Z.R. Traquina, M. Hortsch, N.H.Patel, and C.S. Goodman (1990). Molecular genetics of neuronal recognition in Drosophila: Evolution and function of immunoglobulin superfamily cell adhesion molecules. Cold Spring Harbor Symp. Quant. Biol. 55: 327-340.
Hortsch, M., N.H. Patel, A.J. Bieber, Z.R. Traquina, and C.S. Goodman (1990). Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis. Development 110: 1327-1340.
Perkins, K.P., A. Admon, N. Patel, and R. Tjian (1990). The Drosophila Fos-related AP-1 protein is a developmentally regulated transcription factor. Genes Dev. 4: 822-834.
Hortsch, M., A.J. Bieber, N.H. Patel, and C.S. Goodman (1990). Alternative splicing generates a nervous system specific form of neuroglian. Neuron 4: 697-709.
Patel, N.H., T.B. Kornberg, and C.S. Goodman (1989). Expression of engrailed during segmentation in grasshopper and crayfish. Development 107: 201-212.
Patel, N.H., E. Martin-Blanco, K.G. Coleman, S.J. Poole, M.C. Ellis, T.B. Kornberg, and C.S. Goodman (1989). Expression of engrailed proteins in arthropods, annelids, and chordates. Cell 58: 955-968. [PDF] file in new window
Patel, N.H., B. Schafer, C.S. Goodman, and R. Holmgren (1989). The role of segment polarity genes during Drosophila neurogenesis. Genes Dev. 3: 890-904.
Bieber, A.J., P.M. Snow, M. Hortsch, N.H. Patel, J.R. Jacobs, Z. Traquina, J. Schilling, and C.S. Goodman (1989). Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1. Cell 59: 447-460. [PDF] file in new window
Jacobs, J.R., Y. Hiromi, N.H. Patel, and C.S. Goodman (1989). Lineage, migration, and morphogenesis of longitudinal glia in the Drosophila CNS as revealed by a molecular lineage marker. Neuron 2: 1625-1631. [PDF] file in new window
Snow, P.M., N.H. Patel, A.L. Harrelson, and C.S. Goodman (1987). Neural-specific carbohydrate moiety shared by many surface glycoproteins in Drosophila and grasshopper. Journal of Neuroscience 712: 4137-4144. [PDF] file in new window
Patel, N.H., P.M. Snow, and C.S. Goodman (1987). Characterization and cloning of fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila. Cell 48: 975-988. [PDF] file in new window
Steinberg, M.S., H. Shida, G.J. Giudice, M. Shida, N.H. Patel, and O.W. Blaschuk (1987). On the molecular organization, diversity, and functions of desmosomal proteins. CIBA Foundation Symp. 125: 3-25.
Giudice, G.J., S.M. Cohen, N.H. Patel, and M.S. Steinberg (1983). Immunological comparison of desmosomal components from several bovine tissues. Journal of Cellular Biochemistry 35: 35-45. [PDF] file in new window
Patel, N.H., C.H. Nelson, J.R. Ellison, and B.G. Sanders (1981). Chicken fetal antigen (CFA) expression on the primitive erythroid maturation series. Experimental Hematology 9: 878-885.
Nelson, C.H., N.H. Patel, and B.G. Sanders (1980). Chicken fetal antigen expression on the definitive erythroid maturation series. Journal of Experimental Zoology 212: 101-108.
Nipam H. Patel
